Intrathecal (intraventricular) polymyxin B in the treatment of patients with meningoencephalitis by Acinetobacter baumanii and Pseudomonas aeruginosa
نویسندگان
چکیده
منابع مشابه
Successful treatment of Acinetobacter meningitis with intrathecal polymyxin E.
linezolid 600 mg twice daily. At that time the patient was also receiving venlafaxine 150 mg nocte for depression. Twenty days after commencing the oral antibiotic regimen the patient was noted to be confused and disorientated, with disturbance of his sleep–wake cycle, and was intermittently aggressive. A computed tomography scan of the brain did not reveal any significant abnormality, serum bi...
متن کاملDegradation of phospholipid in Pseudomonas aeruginosa induced by polymyxin B.
Effects of polymyxin B on the synthesis and degradation of lipid, ribonucleic acid (RNA) and protein in Pseudomonas aeruginosa were investigated. It was found that polymyxin B caused a marked degradation of the lipid fraction which was prelabeled with (3H-2)-glycerol. Thin-layer chromatographic analysis indicated that the main degraded lipids were phosphatidylethanolamine and phosphatidylglycer...
متن کاملPharmacodynamics of polymyxin B against Pseudomonas aeruginosa.
Despite limited data, polymyxin B (PB) is increasingly used clinically as the last therapeutic option for multidrug-resistant (MDR) gram-negative bacterial infections. We examined the in vitro pharmacodynamics of PB against four strains of Pseudomonas aeruginosa. Clonal relatedness of the strains was assessed by random amplification of polymorphic DNA. Time-kill studies over 24 h were performed...
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ژورنال
عنوان ژورنال: Critical Care
سال: 2011
ISSN: 1364-8535
DOI: 10.1186/cc9655